pentobarbital will decrease the level or effect of isavuconazonium sulfate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
pentobarbital will lessen the extent or impact of pitolisant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Pitolisant publicity is decreased by 50% if coadministered with strong CYP3A4 inducers.
Remark: Barbiturates may possibly improve adverse effects, including respiratory melancholy, produced by poisonous doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs.
In the event the buprenorphine dose is insufficient and also the CYP3A4 inducer can not be minimized or discontinued, transition the affected individual back to the buprenorphine formulation that allows dose adjustments.
pentobarbital will lessen the extent or result of eucalyptus by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unknown.
pentobarbital will lower the extent or result of lopinavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will lessen the level or impact of eltrombopag by influencing hepatic enzyme CYP2C9/ten metabolism. Use Caution/Check.
Drugs which have amount restrictions connected to Every prescription. This restriction ordinarily restrictions the amount website of your drug that will be coated.
pentobarbital will reduce the extent or influence of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. The efficacy of hormonal contraceptives could possibly be minimized.
benzhydrocodone/acetaminophen and pentobarbital both increase sedation. Keep away from or Use Alternate Drug. Restrict use to individuals for whom choice therapy selections are insufficient
Contraindicated (1)pentobarbital will decrease the extent or result of fostemsavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lessen the level or impact of fosamprenavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Keep track of Carefully (one)pentobarbital will raise the degree or outcome of clopidogrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lower the extent or outcome of fentanyl transmucosal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on to some lessen in fentanyl plasma concentrations, lack of efficacy or, perhaps, enhancement of a withdrawal syndrome within a affected individual who has produced Bodily dependence to fentanyl.